Betaine
-TMG
Research
and Studies
Since
B12, folate, betaine, and B6 have been proven to lower homocysteine levels and
are an inexpensive intervention, supplementation is a prudent preventive
measure in middle-aged to elderly individuals. Alternative Medicine
Review, Feb, 2003 by Alan L. Miller.
Betaine
has been reported to play a role in reducing blood levels of homocysteine, a
toxic breakdown product of amino-acid metabolism that is believed to promote
atherosclerosis and osteoporosis. While the main nutrients involved in controlling
homocysteine levels are folic acid, vitamin B6, and vitamin B12, betaine
has been reported to be helpful in some people whose elevated homocysteine levels
did not improve with these other nutrients. Betaine has also been shown
to be helpful in certain rare genetic disorders involving cysteine metabolism.
Selhub J. Homocysteine metabolism. Annu Rev Nutr 1999;19:217-46 [review].Wendel
U, Bremer HJ. Betaine in the treatment of homocystinuria due to 5,10-methylenetetrahydrofolate
reductase deficiency. Eur J Pediatr 1984;142:147-50. Wilcken DE, Wilcken B,
Dudman NP, Tyrrell PA. Homocystinuria-the effects of betaine in the treatment
of patients not responsive to pyridoxine. N Engl J Med 1983;309:448-53. Gahl
WA, Bernardini I, Chen S, et al. The effect of oral betaine on vertebral body
bone density in pyridoxine-non-responsive homocystinuria. J Inherit Metab Dis
1988;11:291-8. Barak AJ, Beckenhauer HC, Tuma DJ. Betaine, ethanol, and the
liver: a review. Alcohol 1996;13:395-8 [review].
The
first stage of liver damage that results from drinking alcohol is the accumulation
of fat in the liver (alcohol-induced fatty liver disease). Betaine,
because of its lipotropic effects, has been shown to produce significant improvements
in this condition in several human clinical studies. Barak AJ,
Beckenhauer HC, Tuma DJ. Betaine, ethanol, and the liver: a review. Alcohol
1996;13:395-8 [review].Barak AJ, Beckenhauer HC, Badakhsh S, Tuma DJ. The effect
of betaine in reversing alcoholic steatosis. Alcohol Clin Exp Res 1997;21:1100-2.
There
is no doubt that TMG greatly reduces homocysteine levels and improves
health among people with the rare disease cystathionine beta-synthase deficiency
(as well as related conditions).Wilcken DEL, Dudman NPB, Tyrrell
PA. Homocystinuria due to cystathionine beta-synthase deficiency—the effects
of betaine treatment in pyridoxine-responsive patients. Metabolism. 1985;34:1115–1121.
Brain
Tonic's all natural ingredients contribute to a better quality of life.
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