CATECHINS (EGCG – EGC – ECG – EC – GCG)
Research and Studies
Dr.
Stephen Hsu, a cell biologist in the Medical College of Georgia Department of
Oral Biology, has uncovered a wealth of information about green tea in
the last few years. Most importantly, he helped determine that compounds in
green tea called polyphenols help eliminate free radicals, which can
cause cancer by altering DNA. He also found that polyphenols safeguard
healthy cells while ushering cancer cells to their death.
Researchers
have discovered that a component in green tea helps kill cells of the
most common leukemia in the United States. The research using laboratory
cell cultures shows that a component of green tea known as epigallocatechin-3-gallate
(EGCG) [epi-gallo-cat-ekin-3-gal-ate] helps kill leukemia cells by interrupting
the communication signals they need to survive.Mayo Clinic
The
researchers suggest that green tea extracts, which are relatively non-toxic,
may be beneficial in the treatment of patients with head and neck cancers.
Further studies are necessary to determine the proper dosage of the
extract. Dr. Masuda presented these findings at the International Society
of Preventive Oncology meeting in February. The research was published in December
2001 in Clinical Cancer Research.
EGCG
may also inhibit other types of cancers via other growth factor receptors.
Recent evidence from Drs. Masuda and Weinstein indicates that EGCG
inhibits HER2-neu activity in breast cancer cell lines; this natural product,
therefore, may also be useful in treating patients with breast cancer. The
National Foundation for Cancer Research, the T.J. Martell Foundation, and the
Richard and Hinda Rosenthal Center for Complementary and Alternative Medicine
sponsored this research.
Several
components of green tea leaves are known to have natural properties that counteract
the harmful effects of oxidation in the blood. In fact, the principal
and most powerful of these catechins or flavonoids, EGCG (epigallocatechin-3-gallate),
has been shown to provide some protection against the development of inflammation,
tumors and the new blood vessels that support tumor growth. Because
of the antioxidant properties of the catechins in its leaves, tea also
has been seen as a potential dietary intervention for cardiovascular diseases.
Oxidation, which damages the inner surfaces of arteries and encourages the formation
of plaque deposits, is believed to be one factor in the development of atherosclerosis.
Cedars-Sinai Medical Center.
Brain
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